Understanding Anti-Oxidants and Free Radicals

If you want to protect your skin, think antioxidants. These have gained a great deal of attention in recent years, and for good reason.
They work to combat the ‘free radical cells’ that damage your skin.

What are free radicals?

Created when oxygen produces by-products during normal cellular metabolism. More accurately, this reactive oxygen ‘steals’ electrons from proteins, DNA and cell membranes, damaging tissue. If left unchecked, free radicals may cause heart damage, cancer, cataracts, and a weak immune system. Free radicals may be involved with aging of tissue; and coupled with sun damage, could promote skin cancers.

While free radicals are produced by normal human metabolism, they can be increased by smoking, alcohol, exposure to heavy metals, and radiation. Antioxidants counteract this process by binding to the free radicals, transforming them into non-damaging compounds, or repairing cellular damage. It would seem logical, then, to include antioxidants in your daily regime.

To the rescue

Antioxidants are the antidote to free radicals. They can be taken orally or applied directly to the skin. What are antioxidants?
In order for antioxidants to have any benefit they have to be in sufficient quantities in the tissue. Common antioxidants that are taken orally, or eaten, are Vitamin C, Vitamin E, Selenium and the carotenoids, (fruits and vegetables having the most deeply or brightly-colored fruits and vegetables, i.e.: spinach, carrots, red bell peppers, tomatoes).

What are topical antioxidants?

Topical antioxidants may reduce UVA damage. UVA is the wavelength that mostly produces visible signs of sun damage and has some
carcinogenic effect. Topical antioxidants that have been studied in creams or ointments are Vitamin C, Vitamin E, Glutathione, Lipoic Acid, Coenzyme Q10, Soy- isoflavanone. It has been shown that combining some of these have additional benefit.  Others such as selenium, zinc and silymarin have not been studied for their effects.

Which are the antioxidants?

Antioxidants can be divided into those that are fat soluble and those that are water soluble.  Fat soluble is:

* Vitamin E, coenzyme Q10 and lipoic acid

Water soluble is:

* Glutathione and Vitamin C

Vitamin E:

* The antioxidant effect can be more effective if combined with other antioxidants i.e.: coenzyme Q10 and Vitamin C
* Is found in fresh vegetables, oils, seeds, nuts, cumin, and soy. Animal studies have shown that Vitamin E protects against UVB
damage, although this effect has not been proved in humans. (UVB is much more carcinogenic than UVA, and causes sunburns).
* Commonly used to help wound healing. However, studies in human burns did not show Vitamin E helping and about a 1/5 of
patients reacted to vitamin E with a contact dermatitis).
* Topical Vitamin E is commonly used by pregnant women in the belief that it prevents stretch marks. There is no evidence for this,
and sometimes an acute allergic dermatitis is produced causing an inflamed uncomfortable rash.

Coenzyme Q10 (also known as Ubiquinone)

* Found in fish and shell fish
* It penetrates well into skin, and is claimed to reduce the breakdown of collagen after exposure to UVA light
* It may reduce the depth of wrinkles but this has not been confirmed in studies

Lipoic Acid

* This is well absorbed into the skin, and converted quickly into dihydrolipoic acid in the cells. It has an anti-inflammatory effect. A
three per cent application of Lipoid Acid has been shown to reduce redness in the skin after UVB exposure.

Glutathione

* This antioxidant is produced by amino acids, eysteine, glycine and glutamic acid

Vitamin C

* Also known as Ascorbic Acid
* Oral Vitamin C improves wound healing and may enhance the immune system
* The lack of vitamin C produces scurvy, which produces fragile skin and bleeding gums

Topical Vitamin C

* reduces sun damage, fine wrinkles, and may lighten dark skin pigmentation
Green Tea (Tea polyphenols)
When used topically as a cream

* Has shown to reduce the carcinogenic effect of certain chemicals and ultraviolet rays on the skin of animals. We are still awaiting
good evidence for benefit in humans

* Produces anti-inflammatory effects
* Reduces the redness caused by UV light

DHEA (Dehydroepiandrosterone)

* Occurs naturally in our bodies
* When taken orally, DHEA is a powerful antioxidant that may have an anti-aging effect and help thicken skin and reduce
pigmentation
* It is not know if there are any long-term negative effects from oral injection
Soy-isoflavones

* When used topically it may increase collagen and decrease redness and damage from ultraviolet rays
* For more information about caring for your skin, visit the rest of this site.
By Dr. Richard Thomas

Anti-Oxidants And Sun Damaged Skin

Sun damage or photo damage produces both skin cancers as well as photo-aging. Photo-aging shows itself on the skin as wrinkling, scaling, dryness, and mottled pigmentation. Ultra-violet light is absorbed by skin, which in turn produces a photo-chemical reaction.

The UVA light is absorbed by both DNA as well as urocanic acid, the photo-chemical reaction produces oxidation of both DNA, nucleide acid, and protein, as well as lipids, this is known as oxidative damage. Anti-oxidants have been evolved to protect against, and reverse some of the damage produced by sunlight. An anti-oxidant mechanism is very advanced in plants that protect against the damage from sun exposure.

Oxidation:
Oxidation is produced by reactive oxygen molecules. The DNA absorbs ultra-violet light mostly in the UVB (290-320 manometres) range. This produces damage mainly within the epidermis. UVA (320-400 manometres) penetrates deeper into the skin and produces damage in the epidermis, the dermis as well as affecting blood vessels. The UVA has a much more oxidizing effect on cells.

The carcinogenic or cancer forming effects of ultra-violet B produce mutations within the DNA. This initiates tumours within the epidermis. The UVA promotes these tumours as it has much more oxidizing stress on the skin than UVB. It may as a result be more cytotoxic and immunosuppressive.

Sunscreens:
Sunscreens certainly protect against ultra-violet light, the sunburning spectrum is UVB and sunscreens are very effective. Ultra-violet A is the most difficult to protect against. It is important to realize that the SPF numbers are calculated with an amount of sunscreen on skin that exceeds what most of us put on our own skin.

The SPF is calculated with a quantity of 2mg. of sunscreen per centimetre2. Most people will put on about half to one quarter of this when used as sun protection. Unfortunately, low quantities of sunscreen of per centimtre2 will have minimal sun protective effects. Usually if 5mg. per cm.2 of sunscreen is applied to the skin, the sun protective factor is in the region of an SPF of 3.

Anti-Oxidants:
Anti-oxidants play a significant part in the protective and repair mechanisms within animals and plants. This can be achieved by anti-oxidants that are produced within the skin itself or by those consumed or applied from plants. The anti-oxidant effects can be divided into those that have their protection through enzymes, and those that tend to reduce the quantity of hydrogen peroxide as well as lipid hydroperoxides.
Topical Anti-Oxidants:
The use of topical anti-oxidants has certain requirements, these have to be stable as well as being cosmetically acceptable. It is clear that anti-oxidants have a photo-protective benefit. The physiological anti-oxidants include vitamin C, vitamin E, and ubiquinol. Vitamin C is water-soluble and is a free radical scavenger, it is required for collagen synthesis and may inhibit elastin formation in the dermis.

It may also reduce pigment synthesis, as well as enhance epidermal barrier function. For it to be active it must be present on the skin at a pH of 3.5 or lower in order to have an anti-oxidative effect. Vitamin E is different from vitamin C, in that it is lipid soluble, there is evidence that combining vitamin E and vitamin C may be of some benefit. Other anti-oxidants to be considered will be selenium as well as zinc.
Plant Anti-Oxidants:
Plants synthesize vitamin C, vitamin E and flavones, and polyphenolic compounds.

* Silymarin
* Soy isoflavones
* Tea
* Polyphenols

These are all potent plant anti-oxidants.

Silymarin:

This is a Milk Thistle extract, the main component in terms of anti-oxidants is silybyn. This prevents lipid peroxidase action. It also has been shown to inhibit tumour promotion in animals.

Soy isoflavones:
Soy has been connected with a reduction in cardiovascular disease, and in some incidents’ of breast cancer when taken by mouth in large quantities. It has a phytoestrogen effect, which can reduce menopausal symptoms. The isoflavones are genistein and gaidzein. The genistein has a collagen synthesis effect. It is also anti-cancer. It has been used both orally as well as topically.

The genistein is a powerful scavenger of peroxyl radicals. This has a significant reduction in lipid peroxidase activity. It has been shown to reduce redness in the skin of mice which are subject to ultra-violet A. It also has an anti-inflammatory effect. The use of this compound reduces the immune suppression effect of ultra-violet light.

Tea polyphenols:
Tea is fermented initially to green, and then to black tea. The drinking of black tea has been shown to reduce the frequency of squamous cell carcinomas. Work done with green tea both topically and taken orally, shows that it reduces the ability of ultra-violet to produce skin cancers and redness, particularly in animals. The possibility of combining tea, plus vitamin E, to work together as anti-oxidants is interesting.

Much more work needs to be done in order to establish how combining anti-oxidants with sunscreens will have a very beneficial effect on reducing sun damage to skin.

The Benefits of Anti Aging Facial Masks

Skin wrinkles are caused by two main factors: heredity and the environment. There is little you can do about heredity and the natural aging process, but there is something you can do about the other causes. Pollution in the environment, sun exposure and stress can all lead to premature aging of the skin. Using anti aging creams is beneficial for reducing the appearance of wrinkles. The creams are even more effective when combined with regular facials.

Facials counteract the effects of pollutants and sun exposure on your skin. Having regular facials will also help your skin absorb your anti aging creams better. Monthly facials improve elasticity, give your skin a smoother texture and improve the hydration of your skin. In addition, a facial will help remove dead skin which aids in the absorption of other creams or lotions used to combat wrinkles.

The products used for your facial will depend on your skin type. If you have dry skin, a moisturizing mask will be used to help add moisture to the skin. A rich moisturizer will also be used at the end of the treatment. Oil free products will be used for people with oily skin.

Facials can be done at home or by a professional in a salon or spa. Facial massage is very beneficial for wrinkles. The massage increases the blood circulation to the muscles of the face, which helps to minimize the appearance of fine lines and wrinkles. There are over one hundred muscles in the face and massage helps to relax these muscles. This is particularly effective for wrinkles that result from muscle contractions, such as laugh lines and worry lines.

If you want to enjoy the benefits of facial massage, visit a salon for your facial. Facial massage is best done by a professional who is knowledgeable in massage techniques. An inexperienced person may actually cause more harm than good. When the muscles are not massaged properly, they sag which can cause wrinkles to be more prominent. The massage is also very relaxing. At some salons and spas, the arms, neck and shoulders are massaged as well. This is great for stress relief.

The basic facial procedure starts by examining the skin. This will help the professional assess the skin and determine the products that will be of the greatest benefit. Steam is then used to open the pores and remove impurities from the skin. A gentle cleanser is then used to clean the skin. This step is followed by a toner that is appropriate for your skin type. A facial mask is used to soothe and refresh the skin as well as to add moisture. At the end of the massage, a moisturizer that is appropriate for your skin type will be applied.

Once you have had your facial, you will want to keep your skin in good condition at home. Use a gentle cleanser that is not drying in the morning and at night. Invest in good quality anti aging creams to minimize wrinkles and prevent new ones from forming. It’s important to choose creams that are good for your skin type and the condition of your skin. Read reviews to help you choose the best products for your skin.